Dr Jochen Kursawe
Lecturer
- Phone
- +44 (0)1334 46 3716
- Jochen.Kursawe@st-andrews.ac.uk
- Office
- 315 MI
- Location
- Mathematical Institute
Research areas
I develop and apply mathematical and computational methodology to understand questions in developmental biology. I research how individual cells make decisions, for example to divide or differentiate, and how multiple cells interact to form healthy and viable tissues. My work includes analysing the dynamics of gene regulatory interactions and modelling mechanics of single cells and their interactions. My aim is to to decipher the fundamental mechanisms that underly the robustness of patterning and morphogenesis.
PhD supervision
- Kairui Li
- Aimee Bebbington
- Kairui Li
Selected publications
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Open access
Contributions of cell behavior to geometric order in embryonic cartilage
Mathias, S., Adameyko, I., Hellander, A. & Kursawe, J., 29 Nov 2023, In: PLoS Computational Biology. 19, 11, 27 p., e1011658.Research output: Contribution to journal › Article › peer-review
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Open access
Sequential and additive expression of miR-9 precursors control timing of neurogenesis
Soto, X., Burton, J., Manning, C. S., Minchington, T., Lea, R., Lee, J., Kursawe, J., Rattray, M. & Papalopulu, N., 1 Oct 2022, In: Development. 149, 19, 14 p., dev200474.Research output: Contribution to journal › Article › peer-review
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Open access
A dynamic, spatially periodic, micro-pattern of HES5 underlies neurogenesis in the mouse spinal cord
Biga, V., Hawley, J., Soto, X., Johns, E., Han, D., Bennett, H., Adamson, A. D., Kursawe, J., Glendinning, P., Manning, C. S. & Papalopulu, N., 1 May 2021, In: Molecular Systems Biology. 17, 5, 27 p., e9902.Research output: Contribution to journal › Article › peer-review
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Open access
Differential phase register of Hes1 oscillations with mitoses underlies cell-cycle heterogeneity in ER+ breast cancer cells
Sabherwal, N., Rowntree, A., Marinopoulou, E., Pettini, T., Hourihane, S., Thomas, R., Soto, X., Kursawe, J. & Papalopulu, N., 9 Nov 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 45, 12 p., e2113527118.Research output: Contribution to journal › Article › peer-review
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Open access
Inferring kinetic parameters of oscillatory gene regulation from single cell time-series data
Burton, J., Manning, C. S., Rattray, M., Papalopulu, N. & Kursawe, J., Sept 2021, In: Journal of the Royal Society Interface. 18, 182, 15 p., 20210393.Research output: Contribution to journal › Article › peer-review
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Open access
Chaste: Cancer, Heart and Soft Tissue Environment
Cooper, F. R., Baker, R. E., Bernabeu, M. O., Bordas, R., Bowler, L., Bueno-Orovio, A., Byrne, H. M., Carapella, V., Cardone-Noott, L., Cooper, J., Dutta, S., Evans, B. D., Fletcher, A. G., Grogan, J. A., Guo, W., Harvey, D. G., Hendrix, M., Kay, D., Kursawe, J., Maini, P. K., & 9 others , 13 Mar 2020, In: Journal of Open Source Software. 5, 47, p. 1848 8 p.Research output: Contribution to journal › Article › peer-review
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Coupled differentiation and division of embryonic stem cells inferred from clonal snapshots
Ruske, L. J., Kursawe, J., Tsakiridis, A., Wilson, V., Fletcher, A. G., Blythe, R. A. & Schumacher, L. J., 27 Apr 2020, In: ArXiv e-prints.Research output: Contribution to journal › Article
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Open access
Coupled differentiation and division of embryonic stem cells inferred from clonal snapshots
Ruske, L. J., Kursawe, J., Tsakiridis, A., Wilson, V., Fletcher, A., Blythe, R. A. & Schumacher, L. J., 15 Oct 2020, In: Physical Biology. 17, 6, 19 p., 065009.Research output: Contribution to journal › Article › peer-review
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Open access
Dynamic properties of noise and Her6 levels are optimized by miR-9, allowing the decoding of the Her6 oscillator
Soto, X., Biga, V., Kursawe, J., Lea, R., Doostdar, P., Thomas, R. & Papalopulu, N., 17 Jun 2020, In: EMBO Journal. 39, 12, 23 p., e103558.Research output: Contribution to journal › Article › peer-review
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Open access
Quantitative single-cell live imaging links HES5 dynamics with cell-state and fate in murine neurogenesis
Manning, C. S., Biga, V., Boyd, J., Kursawe, J., Ymisson, B., Spiller, D. G., Sanderson, C. M., Galla, T., Rattray, M. & Papalopulu, N., 27 Jun 2019, In: Nature Communications. 10, 19 p., 2835.Research output: Contribution to journal › Article › peer-review